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Publications: Apoptosis (2017-2014)

Chenyi Liao, Zhi Zhang, Justin Kale, David W. Andrews, Jialing Lin & Jianing Li

Conformational Heterogeneity of Bax Helix 9 Dimer for Apoptotic Pore Formation

Scientific Reports 6, Article number: 29502 (2016)

Abstract  Full Text Adobe PDF

Hetal Brahmbhatt, David Uehling, Rima Al-awar, Brian Leber, David Andrews

Small molecules reveal an alternative mechanism of Bax activation

Biochemical Journal, april 2016, 473 (8)

Abstract  Full Text Adobe PDF


Stéphanie Thébault, Morgane Agez, Xiaoke Chi, Johann Stojko, Vincent Cura, Stéphanie B. Telerman, Laurent Maillet, Fabien Gautier, Isabelle Billas-Massobrio, Catherine Birck, Nathalie Troffer-Charlier, Teele Karafin, Joane Honoré, Andrea Senff-Ribeiro, Sylvie Montessuit, Christopher M. Johnson, Philippe Juin, Sarah Cianférani, Jean-Claude Martinou, David W. Andrews, Robert Amson, Adam Telerman and Jean Cavarelli

TCTP contains a BH3-like domain, which instead of inhibiting, activates Bcl-xL

Scientific Reports, Jan 2016, Vol 6

Abstract  Full Text Adobe PDF


Zhi Zhang, Sabareesh Subramaniam, Justin Kale, Chenyi Liao, Bo Huang, Hetal Brahmbhatt, Samson GF Condon, Suzanne M Lapolla, Franklin A Hays1, Jingzhen Ding, Feng He1, Xuejun C Zhang, Jianing Li, Alessandro Senes, David W Andrews and Jialing Lin

BH3-in-groove dimerization initiates and helix 9 dimerization expands Bax pore assembly in membranes

The EMBO Journal, Jan 2016, Vol 35 Issue 2

Abstract  Full Text Adobe PDF


Justin P. Pogmore, James M. Pemberton, Xiaoke Chi, David W. Andrews

Using Förster-Resonance Energy Transfer to Measure Protein Interactions Between Bcl-2 Family Proteins on Mitochondrial Membranes

Methods in Molecular Biology April 2016, Vol 1419

Abstract  Adobe PDF


Shamas-Din A, Bindner S, Chi X, Leber B, Andrews DW, Fradin C.

Distinct lipid effects on tBid and Bim activation of membrane permeabilization by pro-apoptotic Bax

Biochem J. May 2015, Vol 467 Issue 3

Abstract  Full Text Adobe PDF


Osterlund EJ1, Liu Q, David W. Andrews

The use of FLIM-FRET for the detection of mitochondria-associated protein interactions

Methods in Molecular Biology Jan 2015, Vol 1264

Abstract  Adobe PDF

David W. Andrews

Pores of no return

Molecular Cell Nov 2014, Vol 56, Issue 4

Abstract  Full Text Adobe PDF

Xiaoke Chi, Justin Kale, Brian Leber and David W. Andrews

Regulating cell death at, on, and in membranes

Biochimica et Biophysica Acta Sep 2014, Vol 1843, Issue 9, 2100-2113

Abstract  Adobe PDF

Justin Kale, Xiaoke Chi, Brian Leber and David W. Andrews

Examining the molecular mechanism of bcl-2 family proteins at membranes by fluorescence spectroscopy.

Methods in Enzymology 2014, Vol 544, 1-23

Abstract  Adobe PDF

Sanjeevan Shivakumar, Martin Kurylowicz, Nehad Hirmiz, Yaseen Manan, Ouided Friaa, Aisha Shamas-Din, Pourya Masoudian, Brian Leber, David W. Andrews, Cécile Fradinemail

The Proapoptotic Protein tBid Forms Both Superficially Bound and Membrane-Inserted Oligomers

Biophysical Journal May 2014, Vol 106, Issue 10, 2085-2095

Abstract  Full Text  Adobe PDF

A Shamas-Din, D Satsoura, O Khan, W Zhu, B Leber, C Fradin, DW. Andrews

Multiple partners can kiss-and-run: Bax transfers between multiple membranes and permeabilizes those primed by tBid

Cell Death and Disease Apr 2014, Vol 5

Abstract  Full Text  Adobe PDF

Jingzhen Ding, Blaine H. M. Mooers, Zhi Zhang, Justin Kale, Domina Falcone, Jamie McNichol, Bo Huang, Xuejun C. Zhang, Chengguo Xing, David W. Andrews and Jialing Lin

After Embedding in Membranes Antiapoptotic Bcl-XL Protein Binds Both Bcl-2 Homology Region 3 and Helix 1 of Proapoptotic Bax Protein to Inhibit Apoptotic Mitochondrial Permeabilization

The Journal of biological Chemistry March 2014 289 (11)

Abstract Full Text  Adobe PDF

C. Borner, David W. Andrews

The apoptotic pore on mitochondria: are we breaking through or still stuck?

Cell Death and Differentiation Feb 2014 Vol 21 187-191

Full Text  Adobe PDF