are studying the mechanisms by which Bcl-2 family members prevent cell death
that would normally be caused by chemotherapy agents. Our recent data
indicate an unexpected role for Bcl-2 in regulating cell adhesion. This
function of Bcl-2 may explain why in some cancers expression of Bcl-2 is an
indicator of a good prognosis even though it makes that cell type resistant
to chemotherapy drugs. The hypothesis that we are testing is that by
upregulating adhesion Bcl-2 downregulates metastasis.