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Cancer Research


We are studying the mechanisms by which Bcl-2 family members prevent cell death that would normally be caused by chemotherapy agents. Our recent data indicate an unexpected role for Bcl-2 in regulating cell adhesion. This function of Bcl-2 may explain why in some cancers expression of Bcl-2 is an indicator of a good prognosis even though it makes that cell type resistant to chemotherapy drugs. The hypothesis that we are testing is that by upregulating adhesion Bcl-2 downregulates metastasis.