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Apoptosis
Cancer
Protein Targeting
imaging

Protein Targeting


When a signal peptide on a newly synthesized protein exits from the ribosome it and the ribosome are bound by SRP (signal recognition particle) and targeted to the translocon (Sec61 complex) via an interaction with the SRP receptor(SRa, SRb)

Current Projects 


Assembly and function of the translocation machinery including the SRP receptor, Sec61b and Sec61g.

Assembly of the E. coli SRP receptor (FtsY).

Analysis of targeting mechanisms of proteins with tail-anchors including Sec61b and g, Vamp proteins, and the Bcl-2 family of proteins that regulate apoptosis.